Figure 3
From: Long term potentiation, but not depression, in interlamellar hippocampus CA1

The long-term potentiation of the pyramidal to pyramidal connection. A schematic drawing demonstrating the 3D digital holographic photolysis setup (left). The holographic method permitted glutamate photolysis to be directed precisely at multiple sites and depths simultaneously. The light path for multiple glutamate uncaging was marked in purple, electrical stimulation in red. Photolysis for glutamate uncaging allowed us to identify pyramidal neurons connected to patched cells. In the example the pyramidal to pyramidal connection was identified by uncaging-induced synaptic responses at cell 1 and 5 but not at cells 2, 3, 4 (top right). HFS in longitudinal networks depolarized the postsynaptic neurons and potentiated uncaging-induced synaptic responses between individual pairs longitudinally connected CA1 pyramidal neurons (bottom right).