Table 1 Effect of plasticizer on flexibility of different polymer films.

From: Electrospinning over Solvent Casting: Tuning of Mechanical Properties of Membranes

Polymer

Plasticizer

without Plasticizer

with Plasticizer

Application

UTS

(MPa)

% Elongation

at break

Young’s

Modulus

(MPa)

UTS

(MPa)

% Elongation

at break

Young’s

Modulus

(MPa)

PVA7

Sorbitol

14.36

61.23

75.9

5.36

110.81

22.6

Vaginal film

Eudragit RS PO8

Citric Acid

4.46

—

760

1.00

117.11

520

Controlled drug release film

HPMC9

TEC

83.3

8.5

891.1

76.7

107.0

516.9

Transdermal drug delivery

Chitosan and Carbopol10

Glycerol

4.56

44

—

4.5

65

—

Transdermal drug delivery

Zein11

Glycerol

—

—

—

24

0.029

1480

Drug release film

PMVE/MA12

Glycerol

18.23

1.68

24.07

4.73

14.72

1.14

Bioadhesive patch

PMVE/MA13

PEG 10000

—

—

—

31.02

478.43

9.32

Bioadhesive film

PVP-PEGDA-PEG14

PG

0.135

42.5

—

0.09

75

—

Pressure sensitive adhesive

HPC and EC15

PG

10.51

15.51

70.06

7.82

26.62

30.07

Buccal film

Soluplus16

TEC

8.5

2.6

472.4

5.1

178.5

70.0

Drug release film

PPG

13.4

25.9

326.2

6.8

119.6

121.1

 

Glycerin

10.5

47.3

279.1

4.7

195.5

77.5

 

Polymer

Plasticizer

Plasticizer at low level

Plasticizer at high level

Application

UTS

(MPa)

% Elongation

at break

Young’s

Modulus

(MPa)

UTS

(MPa)

% Elongation

at break

Young’s

Modulus

(MPa)

HPMC17

PEG

5.96

106

2.1

4.96

242

0.56

Oral fast dissolving film

Soluplus16

PEG

8.8

66.4

196.0

0.37

461

1.4

Drug release film

HPC18

PEG 400

7.83

51.42

—

6.99

55.91

—

Vaginal film

PMVE/MA12

Glycerol

4.73

14.72

1.14

2.02

36.54

0.04

Bioadhesive patch

Starch19

Glycerol

17.5

1.3

2120

1.2

5.6

26

Bioadhesive film

Cashew gum and CMC20

Glycerol

5.35

0.78

710

1.81

59

3

Biotechnology/packaging

  1. Ref.7. Garg et al.8. Schilling et al.9. Limpongsa et al.10 Silva et al.11 Singh et al.12 Moss et al.13 Singh et al.14 Dana et al.15 Alanazi et al.16 Lim et al.17 Pandey et al.18 Dobaria et al.19 Rechia et al.20 Britto et al. Abbreviations used - UTS: ultimate tensile strength, PVA: poly vinyl alcohol, HPMC: hyrdoxy propyl methyl cellulose, PMVE/MA: (poly) methylvinyl ether/maleic anhydride, PVP: polyvinyl pyrrolidone, PEGDA: poly(ethylene glycol) diacrylate, PEG: polyethylene glycol, HPC: hydroxypropyl cellulose, EC: ethyl cellulose, PG: propylene glycol, TEC: triethyl citrate, PPG: polypropylene glycol, CMC: carboxy methyl cellulose.
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