Table 2 Biomarkers and effects on mPower.

From: Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models

 

mPower

mPower&Slope

λ

Biomarker of SHR

\(\frac{{\alpha }^{(p)}}{{\delta }^{(p)}{\beta }^{(p)}}\)

\(\frac{{\alpha }^{(p)}}{{\delta }^{(p)}{\beta }^{(p)}}+\lambda ({\delta }^{(s)}-{m}^{(s)}-{\theta }^{(s)})\)

0.01

Biomarker of WKY

\(\frac{{\delta }^{(p)}{\alpha }^{(p)}}{{\theta }^{(p)}{\beta }^{(p)}}\)

\(\frac{{\delta }^{(p)}{\alpha }^{(p)}}{{\theta }^{(p)}{\beta }^{(p)}}+\lambda ({m}^{(s)}-{\delta }^{(s)})\)

0.1

Biomarker of WIS

\(\frac{{\theta }^{(p)}{\beta }^{(p)}}{{m}^{(p)}{\alpha }^{(p)}}\)

\(\frac{{\theta }^{(p)}{\beta }^{(p)}}{{m}^{(p)}{\alpha }^{(p)}}+\lambda ({\delta }^{(s)}+{\theta }^{(s)}-{m}^{(s)})\)

0.1

Effect of MPH on SHR

\(\frac{{\theta }^{(p)}}{{\delta }^{(p)}{\alpha }^{(p)}}\)

\(\frac{{\theta }^{(p)}}{{\delta }^{(p)}{\alpha }^{(p)}}+\lambda ({m}^{(s)}+{\theta }^{(s)}-{\delta }^{(s)})\)

0.01

Effect of MPH on WKY

\(\frac{{\theta }^{(p)}{\beta }^{(p)}}{{\delta }^{(p)}{\alpha }^{(p)}}\)

\(\frac{{\theta }^{(p)}{\beta }^{(p)}}{{\delta }^{(p)}{\alpha }^{(p)}}+\lambda ({\delta }^{(s)}-{m}^{(s)})\)

0.01

Effect of MPH on WIS

\(\frac{{\theta }^{(p)}}{{\alpha }^{(p)}}\)

\(\frac{{\theta }^{(p)}}{{\alpha }^{(p)}}+\lambda ({m}^{(s)}-{\delta }^{(s)})\)

0.1

Effect of ATX on SHR

\(\frac{{\delta }^{(p)}}{{m}^{(p)}{\beta }^{(p)}}\)

\(\frac{{\delta }^{(p)}}{{m}^{(p)}{\beta }^{(p)}}+\lambda ({\theta }^{(s)}-{\alpha }^{(s)}-{m}^{(s)})\)

0.01

Effect of ATX on WKY

\(\frac{{\delta }^{(p)}}{{m}^{(p)}{\beta }^{(p)}}\)

\(\frac{{\delta }^{(p)}}{{m}^{(p)}{\beta }^{(p)}}+\lambda ({\theta }^{(s)}-{\alpha }^{(s)}-{m}^{(s)})\)

0.01

Effect of ATX on WIS

\(\frac{{\alpha }^{(p)}}{{\theta }^{(p)}{\beta }^{(p)}}\)

\(\frac{{\alpha }^{(p)}}{{\theta }^{(p)}{\beta }^{(p)}}+\lambda ({\theta }^{(s)}-{\alpha }^{(s)}-{m}^{(s)})\)

0.01