Figure 3
Alterations in protein composition of EVs upon HTLV-1 infection. (A) Venn diagram showing the overlap of proteins identified in EVs from NI and HTLV-1 infected individuals. (B) Volcano plot representing the quantitative analysis of protein composition of EV from NI and HTLV-1 infected donors. Blue and red dots correspond to proteins more abundant in EVs from HD and HTLV-1 infected individuals, respectively. (C) Functional analysis of proteins enriched in EVs from NI. The list of enriched proteins was analyzed with FUNRICH and STRING softwares. The pie chart represents the proportion of proteins associated with coagulation, complement, or the other proteins composing platelet granules. (D) Functional analysis of proteins enriched in EVs from HTLV-1 infected donors. The pie chart represents the proportion of proteins present in lipoproteins, lysosomes or mitochondria.
