Figure 1 | Scientific Reports

Figure 1

From: Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals

Figure 1

The HspA1A-HspA1B cluster originated early during the evolution of placental mammals and shows intraspecies phylogenetic clades. (a) Evolutionary relationships between several mammalian Hsp70s. The evolutionary history was inferred using the Neighbor-Joining (NJ; shown here), Maximum Likelihood (ML), and Maximum Parsimony (MP) methods. The percentage of replicate trees in which the sequences clustered together in the bootstrap test (1000 replicates). Branches supported by all three methods include three bootstrap values (NJ/ML/MP). The evolutionary distances were computed using the JTT matrix-based method and the rate variation among sites was modeled with a gamma distribution (shape parameter = 0.22). All positions containing gaps and missing data were eliminated. (b) The HspA1 genes, HspA1A, HspA1B, and HspA1L are in conserved synteny in all mammals. The collected proteins were mapped to the corresponding mammalian genome sequence and the genomic organization of the HspA1 genes was identified and compared to determine syntenic relationships.

Back to article page