Table 3 Polymorphic sites and density for the three HSPA1 and five neighboring genes reveal that HSPA1A and HSPA1B have low mutational loads. These data are derived from the 1000-Genomes (1000 g) and ExAC datasets. (SNP Density = SNP N/Region Length).
Gene | Region Length (bp) | SNP sites (1000 g) | SNP sites (ExAC) | Density Ratio (ExAC/1000 g) | ||
---|---|---|---|---|---|---|
N | Density# | N | Density | |||
HSPA1A | 2432 | 39 | 0.016 | 46 | 0.019 | 1.2 |
HSPA1B | 2519 | 46 | 0.018 | 83 | 0.033 | 1.8 |
HSPA1L | 6041 | 153 | 0.025 | 307 | 0.051 | 2.0 |
VARS | 18434 | 410 | 0.022 | 961 | 0.052 | 2.3 |
LSM2 | 9587 | 228 | 0.024 | 114 | 0.012 | 0.5 |
C6orf48 | 5155 | 160 | 0.031 | 223 | 0.043 | 1.4 |
NEU | 5246 | 85 | 0.016 | 285 | 0.054 | 3.4 |
SLC44A4 | 15853 | 422 | 0.027 | 647 | 0.041 | 1.5 |