Table 6 Effects of dietary supplementation of broiler breeder hens and their offspring with genistein on broilers’ DEGs for GO clustering analysis related to the immune system.
GO Name | P-value | Genes|Fold change | Count | Pop Hit |
|---|---|---|---|---|
positive regulation of NF-kappa B transcription factor activity | <0.0001 | CIB1|1.75;PRKCB|1.75;CARD11|1.86;TRAF2|1.87;SPHK1|1.95;CD40|2.54;IKBKB|1.85;CHUK|1.75;RNF25|1.83;CTH|1.8914;DDRGK1|1.67;TLR4|1.81;MYD88|1.56;EDA|1.62;TIRAP|1.86;TRIM14|1.98;IRAK2|1.56;EDA2R|1.93;TICAM1|1.56;PSMA6|1.49;TRIM37|1.53;TRIM25|1.52;RPS6KA5|1.50;RIPK4|1.48;NOD1|1.53;WNT5A|2.33;MAP3K13|1.39;MTPN|1.38;FER|1.41;IL1RAP|1.39;TNFRSF11A|1.38;TRAF6|1.40;RIPK1|1.38;UBE2N|1.35;CD40LG|1.90 | 35 | 81 |
positive regulation of defense response to virus by host | <0.0001 | SIN3A|1.75;SELK|1.77;CREB3|2.32;MAVS|1.751;TRAF3IP2|1.46;SMURF1|1.48;MB21D1|1.77 | 7 | 8 |
MyD88-dependent toll-like receptor signaling pathway | 0.0002 | CHUK|1.75;NFKBIA|1.65;NFKB1|1.64;TLR4|1.80;MYD88|1.56;TIRAP|1.86;HSPD1|1.70;IRAK2|1.55;IRF1|1.52;ENSGALG00000009237|1.51;JUN|1.53;MAP2K2|1.488;TRAF6|1.40;TLR7|1.60;IRF-3|1.41;TLR1B|1.45 | 16 | 35 |
toll-like receptor 4 signaling pathway | 0.0006 | CHUK|1.75;PELI1|1.61;NFKBIA|1.66;NFKB1|1.65;TLR4|1.81;MYD88|1.56;TIRAP|1.86;LYN|1.58;JUN|1.53;HMGB1|1.48;MAP2K2|1.50;DAB2IP|1.40;TRAF6|1.40;PIK3AP1|1.38 | 14 | 31 |
positive regulation of type I interferon-mediated signaling pathway | 0.0008 | FADD|1.83;MAVS|1.75;NLRC5|1.60;LSM14A|1.41;WNT5A|2.33;IRF-3|1.41 | 6 | 8 |
toll-like receptor signaling pathway | 0.0008 | TNFAIP3|1.93;CHUK|1.75;PELI1|1.61;CACTIN|1.68;NFKBIA|1.65;NFKB1|1.64;TNIP2|1.89;TLR4|1.80;RPS6KA3|1.55;MYD88|1.56;TIRAP|1.86;HSPD1|1.70;IRAK2|1.55;LYN|1.58;IRF1|1.52;TICAM1|1.56;MAPKAPK2|1.48;ENSGALG00000009237|1.51;JUN|1.53;HMGB1|1.48;MAP2K2|1.48;MAPKAPK3|1.402;DAB2IP|1.40;TRAF6|1.40;PIK3AP1|1.37;TLR7|1.60;IRF-3|1.41;TLR1B|1.45 | 28 | 84 |
toll-like receptor 5 signaling pathway | 0.0008 | TNFAIP3|1.93;CHUK|1.75;NFKBIA|1.65;NFKB1|1.64;MYD88|1.56;TIRAP|1.86;JUN|1.53;MAP2K2|1.48;TRAF6|1.40 | 9 | 16 |
toll-like receptor 2 signaling pathway | 0.0010 | CHUK|1.75;NFKBIA|1.65;NFKB1|1.64;TNIP2|1.89;MYD88|1.56;TIRAP|1.86;LYN|1.58;ENSGALG00000009237|1.51;JUN|1.53;HMGB1|1.48;MAP2K2|1.488;TRAF6|1.40;PIK3AP1|1.37 | 13 | 29 |
toll-like receptor 21 signaling pathway | 0.0024 | CHUK|1.75;NFKBIA|1.65;NFKB1|1.64;MYD88|1.56;JUN|1.53;MAP2K2|1.4881;TRAF6|1.4034 | 7 | 12 |
toll-like receptor 15 signaling pathway | 0.0025 | CHUK|1.75;NFKBIA|1.65;NFKB1|1.648;MYD88|1.56;TIRAP|1.86;JUN|1.53;MAP2K2|1.48;TRAF6|1.40 | 8 | 15 |
positive regulation of B cell proliferation | 0.0033 | CARD11|1.86;CD40|2.53;SASH3|2.01;TFRC|1.91;NCKAP1L|1.97;PELI1|1.61;TLR4|1.80;TICAM1|1.56;MSH6|1.48;CDKN1A|1.66;ATAD5|1.49;PMS2|1.48 | 14 | 36 |
regulation of T cell apoptotic process | 0.0033 | TSC22D3|1.88;FADD|1.83;GPAM|2.180;SIGLEC1|2.10;DOCK8|1.57;VHL|1.54;PDCD1|2.67;CASP8|1.56;WNT5A|2.37;SLC46A2|1.99 | 10 | 22 |
negative regulation of lymphocyte apoptotic process | 0.0037 | TSC22D3|1.88;FADD|1.84;GPAM|2.18;NOC2L|1.63;DOCK8|1.57;VHL|1.55;IRS2|0.60;SLC46A2|2.00;MIF|1.38 | 9 | 19 |
toll-like receptor 7 signaling pathway | 0.0037 | CHUK|1.75;NFKBIA|1.65;NFKB1|1.64;MYD88|1.56;JUN|1.53;MAP2K2|1.481;TRAF6|1.40;PIK3AP1|1.37;TLR7|1.60 | 9 | 19 |
T-helper cell differentiation | 0.0058 | STAT3|2.08;ANXA1|2.93;RC3H2|1.54;ATP7A|1.53;RC3H1|1.52;IL18R1|1.85;STAT6|1.51;HMGB1|1.48;SOCS5|1.47;BATF|2.1;PRKCZ|1.37 | 11 | 27 |
negative regulation of activation-induced cell death of T cells | 0.0063 | TSC22D3|1.88;FADD|1.84;GPAM|2.180 | 3 | 3 |
immunoglobulin secretion | 0.0072 | TRAF2|1.8;CD40|2.53;TRAF3IP2|1.46;TRAF6|1.40;CD40LG|1.90 | 5 | 8 |
activation of NF-kappaB-inducing kinase activity | 0.0084 | CARD11|1.86;TRAF2|1.8;CHUK|1.75;NFKBIA|1.65;NFKB1|1.64;TIRAP|1.86;COPS8|1.46;TRAF6|1.40;MAP3K7|1.36 | 9 | 21 |
negative regulation of T cell apoptotic process | 0.0130 | TSC22D3|1.88;FADD|1.83;GPAM|2.18;DOCK8|1.57;VHL|1.54;SLC46A2|1.98 | 6 | 12 |
regulation of toll-like receptor 4 signaling pathway | 0.0138 | PELI1|1.61;TIRAP|1.86;LYN|1.58;HMGB1|1.48;DAB2IP|1.40 | 5 | 9 |
secretion of lysosomal enzymes | 0.0216 | LYST|1.58;LXR|1.42;GNPTAB|1.34 | 3 | 4 |
regulation of activation-induced cell death of T cells | 0.0216 | TSC22D3|1.88;FADD|1.83;GPAM|2.18 | 3 | 4 |
T-helper 1 cell differentiation | 0.0235 | ANXA1|2.93;IL18R1|1.85;STAT6|1.51;HMGB1|1.48;SOCS5|1.47 | 5 | 10 |
positive regulation of CD4-positive, alpha-beta T cell differentiation | 0.0303 | CD83|1.81;SASH3|2.01;NCKAP1L|1.97;ANXA1|2.93;SOCS5|1.47;PRKCZ|1.37 | 6 | 14 |
regulation of MyD88-dependent toll-like receptor signaling pathway | 0.0339 | IRF1|1.52;IRF-3|1.41 | 2 | 2 |
regulation of B cell receptor signaling pathway | 0.0366 | PRKCB|1.74;PTPN6|1.57;PTPRC|1.56;LYN|1.58;PLCL2|1.50 | 5 | 11 |
regulation of toll-like receptor signaling pathway | 0.0462 | TNFAIP3|1.93;PELI1|1.61;CACTIN|1.68;TIRAP|1.86;LYN|1.58;IRF1|1.52;HMGB1|1.48;DAB2IP|1.40;PIK3AP1|1.37;IRF-3|1.41 | 10 | 31 |
positive regulation of NK T cell differentiation | 0.0465 | TGFBR2|2.027;AP3D1|1.68;AP3B1|1.38 | 3 | 5 |
T-helper cell lineage commitment | 0.0465 | STAT3|2.08;STAT6|1.51;BATF|2.11 | 3 | 5 |
regulation of toll-like receptor 2 signaling pathway | 0.0465 | TIRAP|1.86;LYN|1.58;HMGB1|1.48 | 3 | 5 |
