Figure 2 | Scientific Reports

Figure 2

From: A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

Figure 2

Indeno[1,2,3-cd]pyrene (IP) exposure enhances the severity of allergic lung inflammation in a mild asthmatic murine model. C57BL/6 mice were intranasally exposed to vehicle or various concentrations of IP as indicated and then all immunized and challenged with OVA. Cell subsets (A) and cytokine levels (B) in BALFs were both determined by flow cytometry. The line within the vertical points marks the mean for each group. (C) Serum levels of OVA-specific IgE Abs (mean ± SEM) were measured by ELISA. Data show one of three independent experiments. Eosinophil number, IL-5 and IgE levels showed group differences by one-way ANOVA. *P < 0.05 vs. vehicle-treated group (Mann-Whitney U test).

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