Table 2 Survival time analyses.

From: Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement

 

Model 1&

Model 2*

aHR

95% CI

p-value

aHR

95% CI

p-value

Age (years; per SD)

2.75

(2.36–3.20)

<0.0001

2.69

(2.29–3.16)

<0.0001

Smoking (former vs. non-smoker)

0.96

(0.75–1.22)

0.72

0.95

(0.74–1.22)

0.70

Smoking (current vs. non-smoker)

1.56

(1.12–2.17)

0.0083

1.48

(1.06–2.08)

0.021

Localization (hip vs. knee)

0.83

(0.68–1.02)

0.077

   

BMI (kg/m²; per SD)

1.06

(0.96–1.17)

0.25

§

  

 BMI (25–30 vs <25)

0.97

(0.74–1.26)

0.81

§

  

 BMI (30–35 vs. <25)

1.16

(0.87–1.54)

0.32

§

  

 BMI (>35 vs. <25)

1.22

(0.80–1.86)

0.36

§

  

History of overweight/obesity (yes vs. no)

1.37

(1.11–1.69)

0.0035

1.20

(0.97–1.82)

0.095

Diabetes mellitus type 2 (yes vs. no)

1.59

(1.18–2.15)

0.0024

1.33

(0.98–1.90)

0.067

Gout (yes vs. no)

1.37

(1.05–1.80)

0.023

   

Hypertension (yes vs. no)

1.50

(1.22–1.84)

0.0001

1.31

(1.06–1.62)

0.014

Cardiac infarction (yes vs. no)

1.40

(0.92–2.12)

0.11

   

Cardiac insufficiency (yes vs. no)

1.56

(1.24–1.96)

0.0002

1.32

(1.04–1.69)

0.014

Hypercholesterolemia (reference: no)

 Hypercholesterolemia yes

0.91

(0.73–1.13)

0.38

§

  

 Unknown

1.00

(0.75–1.33)

0.99

§

  

 Cholesterol (mmol/l; per SD)

0.91

(0.81–1.02)

0.10

0.88

(0.79–0.99)

0.035

 Uric acid (mmol/l; per SD)

1.15

(1.03–1.29)

0.017

1.11

(0.99–1.24)

0.081

 hs-CRP (log mg/l; per SD)

1.08

(0.97–1.19)

0.16

   

Laterality of OA (reference: unilateral)

 Bilateral OA

1.53

(1.08–2.16)

0.017

1.28

(0.89–1.82)

0.18

 Unknown

1.76

(1.12–2.76)

0.014

1.53

(0.95–2.45)

0.082

Generalization of OA (reference: not generalized)

 Generalized OA

1.15

(0.91–1.46)

0.24

   

 Unknown

1.17

(0.91–1.52)

0.22

   

Secondary OA (reference: primary)

 Secondary OA

0.73

(0.58–0.90)

0.0040

0.76

(0.61–0.95)

0.017

 Unknown

1.70

(1.01–2.88)

0.047

1.36

(0.77–2.41)

0.29

  1. aHR adjusted Hazard Ratios; CI confidence intervals; SD standard deviation for age 8.75 years, for BMI 4.28 kg/m2, for cholesterol 1.09 mmol/l, for uric acid 84.24 mmol/l, for CRP 1.06 log mg/l; OA osteoarthritis All models are statistically controlled for sex. Bold marked associations revealed p-values below 0.10. &Model 1 shows hazard ratios with 95% confidence intervals adjusted for age, smoking status, and localization. *Model 2 shows all significant mutually adjusted hazard ratios with 95% confidence intervals after backward selection performed “by hand”. §Variables not included in model 2 due to high overlap with other variables. In the final model, only variables with p-values less than 0.10 in at least one substratum were kept.
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