Figure 1 | Scientific Reports

Figure 1

From: Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma

Figure 1

Computational repositioning of FDA-approved drugs using ksRepo. (a) ksRepo workflow schematic. (b) Largest meta-analysis to date of genome-wide expression in VS (n = 80 tumors), yielding 1,335 commonly dysregulated genes, 405 of which are significantly differentially expressed after Bonferroni correction (p < 0.05); ksRepo recommends 8 drugs with high potential for repositioning in sporadic and NF2-associated VS. (c) Drug classes of repositionable candidates from ksRepo analysis. (d) Significant enrichment of anti-inflammatory, anti-neoplastic, and hormone-related drugs from 1,155 FDA-approved drugs after ksRepo analysis (***p < 0.001; black bars, percentage of all drugs in DrugBank that fall within each category; colored bars, percentage of drugs on our ksRepo-recommended shortlist that fall within each category).

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