Figure 3

Tumor size and NF2 mutation type show no relationship with response to mifepristone. (a) MRI scans of six VS patients whose primary tumor cells were treated with mifepristone after surgical resection (for scans of four additional, non-sequenced tumors, see Supplementary Fig. S4). White rectangles, VSs; white circles, second (smaller) VSs in NF2 patients, who presented with bilateral VSs. Scale bars, 20 mm. Scans for VS 1 and VS 4 were conducted without the use of contrast agent due to patient intolerance. (b) Schematic of NF2 gene (above) and resulting mRNA (below), describing mutation locus, mutation type, and resulting amino acid change for each tumor in (a). Tumors 2 and 4 each contained two mutations in the NF2 gene, while for tumors 5 and 6, NF2 mutations were not found.