Figure 5
Results of metabolic activity (MTT), proliferation (BrdU incorporation), and cell death (terminal dUTP nick end labeling, TUNEL) assays performed on HEI-193 and primary VS cells treated for 72 h with other drugs recommended by ksRepo. (a) Treatment with 25 μM prednisolone produces a modest effect on the metabolic activity of primary VS cells in culture; (b) Treatment with 25 μM prednisolone produces no effect on the proliferation of primary VS cells in culture; (c) Treatment with 25 μM prednisolone produces a 15.85% elevation in cell death among primary VS cells when compared to vehicle-treated controls; (d) Treatment with 25 μM prednisolone produces no significant effect on HEI-193 cell metabolic activity; (e) Treatment with 27 μM methylprednisolone produces no significant effect on HEI-193 cell metabolic activity; (f) Treatment with 25, 50, and 100 μM succimer produces no significant effect on HEI-193 cell metabolic activity; (g) Treatment with 25, 50, 100, and 300 μM gold sodium thiomalate produces a significant effect on HEI-193 cell metabolic activity, but only at clinically unreasonable concentrations; (h) Treatment with 5, 10, and 15 μM adenosine monophosphate produces no significant effect on HEI-193 cell metabolic activity.
