Figure 4
From: Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation
Ultrastructural evaluation of mucosal mast cells. Duodenal biopsy samples from healthy volunteers (control) and patients with FD were used to evaluate degranulation of mast cells using transmission electron microscopy. Degree of degranulation (A) and complexity of the granule content (B) in mast cells (n = 28 for controls and n = 19 for patients with FD). (C) Representative transmission electron micrographs of mast cells in mucosal biopsy specimens obtained from a control (left) and a patient with FD (right). Lower panels show representative cytoplasmic granules from each group. Degranulation is present in cells from both groups (arrows). Bars indicate magnification (top panels: 2 µm; low panels: 0.2 µm). **p < 0.01. FD, functional dyspepsia; N, nuclei; PMD, piecemeal degranulation.
