Table 1 Dentate granule cell Fos immunoreactivity levels in Thy1-ChR2 mice.

From: Dynamic interaction of local and transhemispheric networks is necessary for progressive intensification of hippocampal seizures

Hippocampal level

Hemisphere & K-W test

K-W stat.

Fos immunoreactivity per group (intensity, 95% CI)

Bilateral (n = 4)

Ipsilateral (n = 10)

No Activity (n = 7)

Dorso-medial

Ipsilateral

P = 0.0007

11.35

26.1 (20.4–39.9)

P = 0.0434*

34.6 (17.5–39.0)

P = 0.0023**

11.7 (7.1–17.4)

Contralateral

P = 0.0023

10.04

21.1 (17.4–28.0)

P = 0.0038**

12.8 (10.5–14.3)

P = 0.7646

10.2 (5.9–15.1)

Dorso-lateral

Ipsilateral

P = 0.0027

9.827

20.5 (19.7–25.6)

P = 0.0348*

22.5 (13.2–41.8)

P = 0.0072**

11.9 (7.0–14.2)

Contralateral

P = 0.0035

9.500

23.5 (15.6–39.7)

P = 0.0263*

11.9 (8.9–12.9)

P > 0.9999

12.4 (8.7–14.8)

Middle

Ipsilateral

P = 0.0003

12.34

23.1 (17.4–67.1)

P = 0.0047**

19.7 (14.5–30.9)

P = 0.0060**

8.6 (5.4–14.7)

Contralateral

P = 0.0037

9.430

33.4 (22.7–77.1)

P = 0.0237*

11.1 (8.5–12.7)

P > 0.9999

11.0 (3.5–13.9)

Ventral

Ipsilateral

P = 0.0034

9.573

17.8 (17.0–65.6)

P = 0.0117*

16.6 (12.1–29.2)

P = 0.0233*

11.4 (6.3–14.0)

Contralateral

P = 0.0028

9.784

33.4 (15.4–71.5)

P = 0.0356*

10.8 (7.7–13.7)

P = 0.9495

12.9 (8.6–15.2)

  1. Due to data distribution, Kruskal-Wallis test was used, P-values and K-W statistic for overall tests in 2nd & 3rd columns. Data (averaged 8-bit pixel intensity) is presented as median with 95% CI. Dunn’s multiple comparisons test was performed with NA assigned as control, and statistically significant differences in the post-hoc tests are denoted with asterisks: *p < 0.05, **p < 0.01. See also Fig. 3i,j.
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