Table 2 Binned values for AD metrics post-injection of CaMKIIa-ChR2 mice, normalized to pre-injection levels.

From: Dynamic interaction of local and transhemispheric networks is necessary for progressive intensification of hippocampal seizures

 

ANOVA

F stat.

Normalized level to pre-injection (% ±SD)

Post 1 (0–25 min)

Post 2 (25–50min)

Post 3 (50–75min)

Control

hM4D

Control

hM4D

Control

hM4D

AD duration

Ipsi

 

126 ± 41.0

76.6 ± 33.6

168 ± 29.2

88.3 ± 45.1

211 ± 80.1

112 ± 52.7

P = 0.0010

5.679

P = 0.29

P = 0.039*

P = 0.0076**

Contra

 

128 ± 42.9

75.0 ± 33.7

160 ± 26.4

85.1 ± 47.2

208 ± 81.5

109 ± 58.0

P = 0.0020

5.129

P = 0.26

P = 0.063

P = 0.010*

Max amplitude

Ipsi

 

116 ± 29.5

84.9 ± 27.2

233 ± 73.9

90.2 ± 28.0

205 ± 105

96.0 ± 21.1

P = 0.0002

7.537

P = 0.74

P = 0.0005***

P = 0.0075**

Contra

 

95.0 ± 53.7

97.5 ± 11.7

88.9 ± 73.2

105 ± 31.9

103 ± 59.0

98.5 ± 24.7

P = 0.99

0.085

P > 0.99

P = 0.92

P > 0.99

AD coastline

Ipsi

 

190 ± 147

72.8 ± 60.2

403 ± 234

99.4 ± 73.7

409 ± 197

146 ± 98.0

P = 0.0009

5.827

P = 0.46

P = 0.0049**

P = 0.016*

Contra

 

130 ± 102

71.9 ± 50.0

160 ± 155

108 ± 86.9

191 ± 117

151 ± 123

P = 0.54

0.824

P = 0.77

P = 0.82

P = 0.91

  1. Control (n = 5), hM4D (n = 6). Values are binned from five successive stimulations, post injection. Overall significance levels and F statistic by one-way ANOVA is given in the 2nd and 3rd columns. Significance in Sidak’s post test (comparing control vs hM4D for each bin pairwise) is denoted with P-values underneath each pair. *P < 0.05, **P < 0.01, ***P < 0.001.
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