Figure 5
From: Quantifying extracellular matrix turnover in human lung scaffold cultures
Matrisome protein turnover profiles in scaffold cultures. Mass spectrometric analysis of scaffolds repopulated with fibroblasts producing proteins containing stable isotope labeled amino acids. (A) Heat map showing the temporal profiles for matrisome proteins produced in scaffold culture (new), data scaled by column. Three sub clusters discussed in the text are marked with roman numerals. (B) Weighted scatter plot for ECM glycoproteins. Amount of newly synthesized proteins are represented by the size of the data points, ratio of new-to-old protein displayed on Y-axis with equal amount of new and old proteins at the dashed line. For schematic outline of the Figure type see Fig. 3B,C. (C) Weighted scatter plot for Proteoglycans, (D) ECM Regulators, (E) ECM-affiliated Proteins.
