Figure 1
From: Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
Downregulation of SVCT2 in breast cancer. (a) RNA-seq of 113 paired normal breast tissue/breast cancer available in the TCGA dataset shows that the mRNA levels of SVCT2 are decreased in many cancer samples compared to controls (P = 2.31 × 10−19). In contrast TETs remain unchanged or increased in the majority of breast cancer cases. Each line represents an individual patient, linking the level of mRNA in the normal tissue and tumor tissue from that specific patient. (b) Quantitative RT-PCR shows that SVCT2 mRNA levels were decreased in breast cancer cell lines. (c) The mRNA level of TETs was either increased or decreased in breast cancer cell lines shown by quantitative RT-PCR.
