Table 3 Top association signals (P < 5 × 10−8) from meta-analysis.

From: Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS)

SNP

Chr:Pos (hg19)

RAFa

Trait

Gene

Annotation

IRASFS

Meta-analysis

N

P

N

P

rs2072560

11:116661826

0.13

TG

APOA5

intron

1205

5.14E-10

4241

5.67E-16

rs651821

11:116662579

0.14

TG

APOA5

intron

1205

3.67E-10

4241

2.66E-15

rs2070665

11:116707684

0.17

TG

APOA1

intron

1205

4.10E-05

4241

7.03E-09

rs1532625

16:57005301

0.38

HDL

CETP

intron

1205

2.46E-07

4235

7.72E-14

rs11076176

16:57007446

0.28

HDL

CETP

intron

1205

3.87E-06

4235

2.15E-08

rs1160983

19:45397229

0.027

LDL

TOMM40

synonymous

1205

8.61E-06

4177

4.44E-17

  1. aReference allele frequency based on the IRASFS cohort.