Figure 6 | Scientific Reports

Figure 6

From: Attraction and Compaction of Migratory Breast Cancer Cells by Bone Matrix Proteins through Tumor-Osteocyte Interactions

Figure 6

Effect of mass spectrometry-predicted proteins present in osteocyte-conditioned media on tumor spheroid formation. Of note, cn = control, fib = fibronectin, col = type I collagen, big = biglycan, SPARC = osteonectin, FSTL1 = follistatin-related protein 1, and fbn2 = fibulin 2. (A) List of proteins present in MLO-A5 and MLO-Y4 media but not in RAW264.7 media. (B) Primary, TMD, and BMD cell spheroid formation after 24 h in the presence of mass spectrometry-predicted proteins. (C) TMD spheroids 72 h after incubation in the presence of mass spectrometry-predicted proteins. (D & E) Changes in spheroid cross-sectional area in response to the mass spectrometry-predicted proteins. An asterisk (*) denotes statistical significance (p < 0.05) compared to control.

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