Table 1 Inhibitor series characterised and compared in this study.

From: Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses

Drug

Structure

Reference

P2X7 antagonists

CE-224,535

17

AZD9056

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18

25 (from [1]

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19

26 (from [1]

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19

Diarylsulfonylurea inflammasome inhibitor series

Glyburide

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20

CP-412,245

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20

CP-424,174

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20

CRID1

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21

CRID2

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21

MCC950

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21,22

NBC inflammasome inhibitor series

BC7

38

BC23

39

NBC6

24

NBC11

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24

NBC12

24

NBC13

24

NBC19

24

Caspase-1 inhibitor

VX-765

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23

  1. Drugs targeting different points of the NLRP3 pathway assessed in this study. Shown is the name, structure, and original reference for the compounds tested. Compounds tested belong to one of 4 inhibitor classes: P2X7 receptor inhibitors, diarylsulphonylurea inhibitors, NBC series inhibitors, and a caspase-1 inhibitor.
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