Table 1 Thyroid phenotypes detected in F0 crispant larvae.
dysgenesis phenotypes | ||||
target: nkx2.4b exon 1 | ||||
non-injected | crispants | |||
phenotype | — | none | hypoplasia | athyreosis |
N (%) | 66 | 91 (53.2) | 55 (32.2) | 25 (14.6) |
target: nkx2.4b exon 2 | ||||
non-injected | crispants | |||
phenotype | — | none | hypoplasia | athyreosis |
N (%) | 83 | 207 (51.2) | 116 (28.7) | 81 (20.0) |
target: pax2a exon 2 | ||||
non-injected | crispants | |||
phenotype | — | none | hypoplasia | athyreosis |
N (%) | 105 | 118 (50.9) | 43 (18.5) | 71 (30.6) |
dyshormonogenesis phenotypes | ||||
target: tshr exon 4 | ||||
non-injected | crispants | |||
phenotype | — | none | hypoplasia, decreased T4 | |
N (%) | 145 | 191 (45.5) | 229 (54.5) | |
target: tshr exon 10 | ||||
non-injected | crispants | |||
phenotype | — | none | hypoplasia, decreased T4 | |
N (%) | 62 | 104 (60.1) | 69 (39.9) | |
target: duox exon 23 | ||||
non-injected | crispants | |||
phenotype | — | none | decreased T4 | hyperplasia/decreased T4 |
N (%) | 47 | 29 (16.6) | 15 (8.6) | 131 (74.9) |
target: duoxa exon 2 | ||||
non-injected | crispants | |||
phenotype | — | none | decreased T4 | hyperplasia/decreased T4 |
N (%) | 138 | 74 (49.7) | 26 (17.5) | 49 (32.9) |
