Table 2 Final parameter estimates.

From: Improving treatment outcome assessment in a mouse tuberculosis model

Parameter

Description

Parameter estimate

Standard error (%CV)a

pbase

Baseline probability of no cure

1 FIX

—

Emax

Maximum achievable probability of cure

1 FIX

—

T50RpZHE/RZME (months)b

The treatment time at which half the Emax is reached for RpZHE and RZME

2.87

5.4

T50RZMH (months)b

The treatment time at which half the Emax is reached for RZMH

4.35

6.0

γ

Shape factor

9.82

23.0

  1. Rp = rifapentine, Z = pyrazinamide, M = moxifloxacin, H = isoniazid, E = Ethambutol; CV coefficient of variance; aThe standard errors were calculated using the covariance step in NONMEM; bT50 was significantly different between treatment arms (no statistically significant differences were found in other parameters).
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