Table 1 Significantly upregulated proteins during storage (low in control cells).
Gene Symbol | Gene Description | Biological function |
|---|---|---|
ACOX1 | Peroxisomal acyl-coenzyme A oxidase 1 | Desaturation of acyl-CoAs to 2-trans-enoyl-CoAs |
ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase | Synthesis of proline, ornithine and arginine |
AP2A1 | AP-2 complex subunit alpha-1 | Component of the adaptor protein complex 2; clathrin-dependent endocytosis |
ARHGAP1 | Rho GTPase-activating protein 1 | GTPase activator for Rho, Rac and Cdc42 |
ARMT1 | Protein-glutamate O-methyltransferase | Formation of gamma-glutamyl methyl ester residues |
BCLAF1 | Bcl-2-associated transcription factor 1 | Death-promoting transcriptional repressor |
DAZAP1 | DAZ-associated protein 1 | RNA-binding protein; possibly required in spermatogenesis |
DBI | Acyl-CoA-binding protein | Possible intracellular carrier of acyl-CoA esters |
DBT | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | Conversion of alpha-keto acids to acyl-CoA and CO2 |
DDX23 | Probable ATP-dependent RNA helicase DDX23 | Pre-mRNA splicing |
DNAJC3 | DnaJ homolog subfamily C member 3 | Unfolded protein response during endoplasmic reticulum stress |
DSP | Desmoplakin | Anchoring of intermediate filaments to desmosomes |
EIF6 | Eukaryotic translation initiation factor 6 | Prevents the association of the 60S ribosomal subunit with the 40S subunit |
EPM2AIP1 | EPM2A-interacting protein 1 | Unknown |
EZR | Ezrin | Connection of cytoskeletal structures to the plasma membrane; formation of microvilli |
FARSB | Phenylalanine–tRNA ligase beta subunit | Regulatory tRNA ligase beta subunit |
FBN2 | Fibrillin-2 | Component of extracellular calcium-binding microfibrils; regulation of elastic fibers |
FLOT1 | Flotillin-1 | Possible scaffolding protein within caveolar membranes; formation of caveolae |
FUCA2 | Plasma alpha-L-fucosidase | Hydrolyzation of glycoproteins |
GATM | Glycine amidinotransferase, mitochondrial | Synthesis of creatine precursor guanidinoacetate |
GDAP2 | Ganglioside-induced differentiation-associated protein 2 | Unknown |
HIST1H4A | Histone H4 | Core nucleosome component |
HNRNPD | Heterogeneous nuclear ribonucleoprotein D0 | RNA-binding protein |
HNRNPH1 | Heterogeneous nuclear ribonucleoprotein H | Pre-mRNA processing |
HNRNPM | Heterogeneous nuclear ribonucleoprotein M | Pre-mRNA binding protein |
HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Interconversion of testosterone and androstenedione; estradiol and estrone |
KIAA1468 | LisH domain and HEAT repeat-containing protein KIAA1468 | Unknown |
KTN1 | Kinectin | Kinesin-driven vesicle motility |
LRPPRC | Leucine-rich PPR motif-containing protein, mitochondrial | Nuclear and mitochondrial RNA metabolism |
LRRC8A | Volume-regulated anion channel subunit LRRC8A | Essential component of the volume-regulated anion channel |
LRSAM1 | E3 ubiquitin-protein ligase LRSAM1 | Regulation of signaling pathways, cell adhesion, self-ubiquitylation, and cargo sorting during receptor endocytosis |
MRPL28 | 39S ribosomal protein L28, mitochondrial | Component of the 39S mitochondrial ribosome subunit |
MRRF | Ribosome-recycling factor, mitochondrial | Release of ribosomes from mRNA |
MYH9 | Myosin-9 | Cytokinesis, cell shape, secretion |
MYO7A | Unconventional myosin-VIIa | Intracellular movements |
NUDT19 | Nucleoside diphosphate-linked moiety X motif 19 | Hydrolysis various CoA esters |
NUP155 | Nuclear pore complex protein Nup155 | Component of the nuclear pore complex |
PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | Conversion of pyruvate to acetyl-CoA and CO2 |
POLR2E | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | Subunit of RNA polymerase II |
PRCP | Lysosomal Pro-X carboxypeptidase | Cleavage of C-terminal amino acids |
PRDX2 | Peroxiredoxin-2 | Involved in redox regulation of the cell |
PRDX3 | Thioredoxin-dependent peroxide reductase, mitochondrial | Involved in redox regulation of the cell |
PRKCSH | Glucosidase 2 subunit beta | Beta-subunit of glucosidase II, an ER glycan-processing enzyme |
PRKDC | DNA-dependent protein kinase catalytic subunit | DNA double-strand break repair |
PRPF8 | Pre-mRNA-processing-splicing factor 8 | Assembly of spliceosomal proteins |
PRPS2 | Ribose-phosphate pyrophosphokinase 2 | Synthesis of phosphoribosylpyrophosphate (PRPP), essential for nucleotide synthesis |
PTCD3 | Pentatricopeptide repeat domain-containing protein 3, mitochondrial | Mitochondrial RNA-binding protein |
PTPRA | Receptor-type tyrosine-protein phosphatase alpha | Regulation of integrin signaling, cell adhesion and proliferation |
RAB7A | Ras-related protein Rab-7a | Key regulator in endo-lysosomal trafficking |
RPL18 | 60S ribosomal protein L18 | Component of the ribosomal 60S subunit |
RPL37A | 60S ribosomal protein L37a | Component of the ribosomal 60S subunit |
SLC25A3 | Phosphate carrier protein, mitochondrial | Transport of phosphate groups from the cytosol to the mitochondrial matrix |
SOSTDC1 | Sclerostin domain-containing protein 1 | Bone morphogenetic protein antagonist |
SRP54 | Signal recognition particle 54 kDa protein | Transfer of presecretory protein from ribosomes to TRAM (translocating chain-associating membrane protein) |
STAG2 | Cohesin subunit SA-2 | Component of the cohesin complex |
SUCLG2 | Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial | Citric acid cycle |
SULT1A1 | Sulfotransferase 1A1 | Sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters |
TOR1A | Torsin-1A | Protein folding, processing, stability and localization |
TRA2B | Transformer-2 protein homolog beta | Pre-mRNA splicing |
UBA1 | Ubiquitin-like modifier-activating enzyme 1 | Ubiquitin conjugation |
VPS18 | Vacuolar protein sorting-associated protein 18 homolog | Vesicle-mediated protein trafficking to lysosomal compartments |
