Table 1 Gene expression Interferon Scores A and B.

Gene	Reference from literature		Module			Rotated factor loading
Gene	Subsets	PB	1.2	3.4	5.12	Factor 1:IFN Score-A	Factor 2: IFN Score-B
ISG15	^{16, 41, 42}	^{20, 23, 24, 43}	•			0.96*
IFI44	^{16, 41, 42, 44}	^{20, 23, 33, 34, 43, 45}	•			0.80*
IFI27	^{41, 42, 44}	^{20, 33, 34}				0.77*
CXCL10	^{41, 42, 44}	⁶	•			0.71*	(−0.41)
RSAD2	^{16, 42}	^{20, 33, 43}	•			0.70*
IFIT1	^{41, 42, 44}	^{43, 45}	•			0.67*
IFI44L	^{16, 41, 42}	^{20, 24, 33, 43}	•			0.66*
CCL8	⁴¹	⁶		•		0.58*
XAF1	^{41, 42}	^{23, 24, 43, 45}	•			0.54*
IFI6	^{16, 41, 42}	^{20, 24, 33}				0.51	0.45
GBP1	^{41, 42}	⁶		•		0.46*
IRF7	^{16, 41, 42}	⁴³		•		0.46*
CEACAM1	⁴²	⁶		•		0.45*
HERC5	^{16, 41, 42}	²⁰	•			0.43	0.59
EIF2AK2	^{16, 41, 42}	⁴⁵		•		0.42	0.64
MX1	^{16, 41, 42}	^{20, 23, 24, 43}	•			0.40	0.56
LAMP3	^{41, 42}	⁴³	•				0.40*
IFIH1	^{41, 42}	⁴³		•			0.45*
PHF11	⁴¹	⁶			•		0.58*
SERPING1	^{41, 42}	²⁴	•				0.60*
IFI16	^{41, 42, 44}	⁶			•		0.64*
BST2	^{41, 42, 44}	^{6, 43}			•		0.74*
SP100	^{42, 44}	⁶			•		0.74*
NT5C3B		⁶			•		0.80*
SOCS1	^{41, 42}	⁶		•			0.84*
TRIM38	⁴¹	⁶			•		0.87*
UNC93B1	⁴¹	⁶			•		0.88*
UBE2L6	^{16, 42}	⁴³		•			0.89*
STAT1	^{16, 41, 44}	⁶		•			0.94*
TAP1	^{16, 44}	⁴³			•		0.98*
CASP1	^{41, 42}	⁶			•	<0.40	<0.40

Rotated factor loadings show the results of factor analysis. Values are substantive factor loadings (promax; pattern matrix exceeding 0.4) after rotation. *Indicates genes that were included in the factor scores. See supplementary material for further details of factor analysis.

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