Figure 2
From: Defective immuno- and thymoproteasome assembly causes severe immunodeficiency
Phenotypic comparison of 8-week-old homozygous TUB6 mutants and wild type littermates. (a) Body weight data (n = 8–10 per group). (b) Flow cytometric profile of peripheral blood leukocytes (pooled, hom n = 11, WT n = 44). The right box plot shows granulocyte counts after equal acquisition time per sample, normalised to the mean of wild types. For flow cytometry dot plots see Supplementary Fig. S2. (c–e) Representative (immuno-)histological images of spleen (c), neck skin (e) and further indicated organs (d) stained with HE (c,e), anti-CD3 or anti-B220 (c) as indicated, or anti-MPO (d). (f) Cytokine concentration in plasma.
