Figure 6 | Scientific Reports

Figure 6

From: Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation

Figure 6

Schematic illustration of nascent HDL generation by ABCA1. ABCA1 monomers translocate PC and cholesterol in an ATP-dependent manner and sequester them within ECDs (Step 1). When enough PC and cholesterol have been sequestered by the ECDs, the ECDs undergo conformational changes that lead to dimer formation and to the halting of their diffusive movement (Step 2). Lipid-free apoA-I molecules may bind directly to the ECDs of ABCA1 dimers (Step 3), and become loaded with lipids sequestered within the ECDs. Nascent HDL is generated and the ABCA1 dimer dissociates into monomers upon releasing the sequestered lipids (Step 4), thereby returning to Step 1.

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