Figure 1 | Scientific Reports

Figure 1

From: Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals

Figure 1

The construction of 3B12A intrabodies against misfolded TDP-43. (a) DNA and peptide sequences of VH (left panel) and VL (right panel). VH contains residues with high PEST score, thus referred to as a PEST-like sequence, in the CDR2 domain. (b) Domain profiles of 3B12A intrabodies. After cloning cDNAs encoding variable fragments of the heavy chain (VH) and light chain (VL) from a hybridoma expressing 3B12A IgG, we constructed plasmids encoding single-chain variable fragments (scFv) as 3B12A intrabodies with Myc-tag.

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