Figure 5
From: Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β
Structure of AduFab with bound Aβ1-11 peptide. (a) Cartoon representation of AduFab showing heavy chain in green, light chain in cyan, and Aβ1-11 peptide in magenta, with nitrogen and oxygen atoms displayed in blue and red, respectively. L1 to L3 and H1 to H3 indicate the CDRs in the light and heavy chain, respectively. (b) Detailed view of the binding interface between AduFab and the Aβ1-11 peptide, with key interface residues of AduFab within 4 Å of the Aβ peptide shown and labeled. An omit electron density map contoured at 3.0 σ is shown as mesh and superposed on the Aβ peptide.
