Table 3 Binding affinity of aducanumab for truncated Aβ peptides.
From: Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β
Aβ peptide | Binding activity (EC50, nM) | Fold reduction (relative to Aβ1-42) |
|---|---|---|
1–42a | 0.34 | 1.0 |
1–9a | 0.54 | 1.4 |
1–12a | 0.55 | 1.4 |
1–16a | 0.50 | 1.3 |
2–42 | 0.36 | 1.0 |
3–42 | 0.54 | 1.4 |
pE3–42b | 12 | 31 |
4–42 | 15 | 41 |
5–42 | 36 | 96 |
6–42 | 140 | 390 |
8–42 | 150 | 400 |
