Figure 4
From: On the use of Parylene C polymer as substrate for peripheral nerve electrodes
Detailed evaluation of tissue capsule by TEM. (A–F) Representative images of the tissue capsule at 1 and 2 days, 2, 8, 16 and 32 weeks postimplant. Scale bar = 10 µm. At (A) 1 day, (B) 2 days and (C) 2 weeks only amoeboid cells (arrows) were seen in the vicinity of the device. From (D) week 8 two different zones can be distinguished in the capsule (dotted line), with spindle-shaped cells localized at the periphery of the capsule (arrowheads). After (E) 16 and (F) 32 weeks post-implant, the capsule was mainly formed by spindle-shaped cells and collagen fibers (insets, G–L). Insets show the progressive change from (G–H) amoeboid cells at early time points to (I–L) spindle-shaped cells, together with an increase in (K–L) collagen deposition from 8 weeks. Scale bar = 2 µm.
