Figure 3 | Scientific Reports

Figure 3

From: Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis

Figure 3

Cartilage-specific Elf3 deficiency attenuates the development of osteoarthritis in mice following destabilization of the medial meniscus (DMM). Representative Safranin O/Fast green-stained sections of the knee joints of DMM-operated 12-week-old male WT and cKO mice at (A) 4 weeks (WT = 7; cKO = 7), (C) 8 weeks (WT = 10; cKO = 11), and (E) 12 weeks (WT = 7; cKO = 8). Images show the medial femorotibial compartment of DMM-operated knees using 10X magnification. The arrows indicate sites of cartilage lesions. Quantification of cartilage damage in WT and cKO mice at 4 (B), 8 (D), and 12 (F) weeks following DMM is shown as OARSI SUM and MAX scores and represented as median and C.I. *p < 0.05 and **p < 0.01 by Mann-Whitney test.

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