Figure 3
Amyloid pathology is not affected by selenium treatment in 3xTg-AD mice. (A) Cerebral amyloid pathology in 3xTg-AD mice at 13–14 months of age. Coronal brain sections of vehicle- (Veh) and Se-treated 3xTg-AD mice were stained with an Aβ antibody (6E10) to reveal the presence of intraneuronal Aβ (middle image) and amyloid plaques (right image) in the hippocampus. The middle and right images are magnified images of the left dashed areas (insets) corresponding to CA1 and subiculum subregions. Scale bars = 40 μm and 250 μm. (B) Quantification of amyloid pathology in the treated groups. Results include number of dense, sparse or total Aβ plaques and intraneuronal Aβ-positive neurons per section, for brain regions shown in (A) Data represent mean number ± s.e.m. n = 4–5 sections/mouse; n = 6–7 mice/group.
