Table 2 Functional characteristics in cells of the viral miRNA identified by sequencing in human plasma.

From: Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population

Viral miRNA

Cell

Function

Plasma presence

Ref.

ebv-miR-BART11-5p

B-cell

Targets EBF-1, critical for B-cell germinal center formation, possibly regulating the expression of EBV latency genes

Not known

23

kshv-miR-K12-10a-5p/aka kshv-miR-K12-10a*

 

Not known

Not known

51

hcmv-miR-US25-2-3p

fibroblast

Reduces viral replication, and viral titers by downregulation of host’s eIF4A1 and consequent protein translation

Not known

21,22

  1. *Functional targets for kshv-miR-K12-10a-5p in cells have not been described, contrary to kshv-miR-K12-10a-3p (previously known as kshv-miR-K12-10a) that mediates cytokine secretion, cell survival, and KSHV gene expression52,53.
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