Figure 4
From: Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney
Hox mutant kidney tubules develop ambiguous nephron segmentation. Intermixed DBA (collecting duct) and LTA (proximal tubule) positive cells were present in E18.5 all heterozygous/homozygous mutants generated (Hoxa9,10,11−/− Hoxc9,10,11+/−, Hoxa9,10,11+/− Hoxc9,10,11−/−, Hoxc9,10,11−/− Hoxd9,10,11+/−, Hoxc9,10,11+/− Hoxd9,10,11−/−) (B’,F’; arrows) but were more frequent in Hoxc9,10,11−/− Hoxd9,10,11−/− embryonic kidneys (C’,G’; arrows) and Hoxa9,10−/−11+/− Hoxc9,10,11−/− (data not shown). Adult Hox mutants that develop cysts showed numberous tubules with intermixed DBA and LTA positive cells (H’,L’); (asterisk).
