Figure 6
From: Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney
Scanning electron microscopy confirmed abnormal cell morphologies in adult multi-Hox mutant cystic kidneys. Mutant tubules showed regions of tightly packed microvilli consistent with proximal tubule brush border (i) interspersed among distal tubule/collecting duct cells37 (ii) with sparse microvilli (C’; higher magnification in C”). Conversely, cystic tubules consisting of primarily proximal tubule cells (i) contained interspersed cells with short, sparse microvilli37 (ii) consistent with distal tubule/collecting duct cells28,37 (D’; higher magnification in D”), not observed in control kidney proximal tubules (A’) or collecting ducts (B’). N = 3 controls and 4 mutants.
