Table 3 Comparison of 64Cu-CB-TE2A-G-ZHER2:342, 64Cu-CB-TE2A-GEEE-ZHER2:342 and 64Cu-NODAGA-ZHER2:S1 tumor-to-organ ratios in nude mice bearing SKOV-3 xenografts. Data are presented as mean ± SD for four mice.
From: Molecular design of radiocopper-labelled Affibody molecules
Tumor-to-organ ratio | |||||||||
---|---|---|---|---|---|---|---|---|---|
2 h | 6 h | 24 h | |||||||
64Cu-CB-TE2A-GEEE-ZHER2:342 | 64Cu-CB-TE2A-G-ZHER2:342 | 64Cu-NODAGA-ZHER2:S1 | 64Cu-CB-TE2A-GEEE-ZHER2:342 | 64Cu-CB-TE2A-G-ZHER2:342 | 64Cu-NODAGA-ZHER2:S1 | 64Cu-CB-TE2A-GEEE-ZHER2:342 | 64Cu-CB-TE2A-G-ZHER2:342 | 64Cu-NODAGA-ZHER2:S1 | |
Blood | 95 ± 21 | 61 ± 18 | 41 ± 8c | 185 ± 66 | 134 ± 36b | 29 ± 13c | 162 ± 39 | 140 ± 53b | 22 ± 7c |
Lung | 25 ± 6a | 14 ± 4 | 8 ± 2c | 39 ± 14a | 20 ± 6b | 6 ± 3c | 34 ± 8 | 23 ± 7b | 4 ± 1c |
Liver | 11 ± 3a | 1.9 ± 0.2 | 3 ± 1c | 13 ± 4a | 2.2 ± 0.7 | 2.1 ± 0.9c | 15 ± 3a | 2.7 ± 0.8 | 2.3 ± 0.7c |
Spleen | 35 ± 8a | 17 ± 3 | 18 ± 4c | 44 ± 14a | 18 ± 4 | 13 ± 5c | 40 ± 12 | 24 ± 10 | 10 ± 3c |
Stomach | 28 ± 7 | 19 ± 4b | 8 ± 2c | 42 ± 13 | 25 ± 7b | 6 ± 3c | 53 ± 15 | 30 ± 15b | 7 ± 2c |
Kidney | 0.04 ± 0.01 | 0.05 ± 0.01 | 0.04 ± 0.01 | 0.06 ± 0.02 | 0.06 ± 0.01 | 0.04 ± 0.02 | 0.06 ± 0.01 | 0.10 ± 0.03 | 0.14 ± 0.04c |
Muscle | 116 ± 35 | 86 ± 16 | 57 ± 19c | 181 ± 52 | 118 ± 43b | 47 ± 20c | 194 ± 72 | 149 ± 59 | 41 ± 14c |
Bone | 46 ± 12a | 27 ± 2 | 25 ± 5 | 87 ± 30a | 38 ± 11 | 22 ± 6c | 81 ± 7a | 36 ± 4b | 20 ± 8c |