Table 3 Comparison of 64Cu-CB-TE2A-G-ZHER2:342, 64Cu-CB-TE2A-GEEE-ZHER2:342 and 64Cu-NODAGA-ZHER2:S1 tumor-to-organ ratios in nude mice bearing SKOV-3 xenografts. Data are presented as mean ± SD for four mice.

From: Molecular design of radiocopper-labelled Affibody molecules

 

Tumor-to-organ ratio

2 h

6 h

24 h

64Cu-CB-TE2A-GEEE-ZHER2:342

64Cu-CB-TE2A-G-ZHER2:342

64Cu-NODAGA-ZHER2:S1

64Cu-CB-TE2A-GEEE-ZHER2:342

64Cu-CB-TE2A-G-ZHER2:342

64Cu-NODAGA-ZHER2:S1

64Cu-CB-TE2A-GEEE-ZHER2:342

64Cu-CB-TE2A-G-ZHER2:342

64Cu-NODAGA-ZHER2:S1

Blood

95 ± 21

61 ± 18

41 ± 8c

185 ± 66

134 ± 36b

29 ± 13c

162 ± 39

140 ± 53b

22 ± 7c

Lung

25 ± 6a

14 ± 4

8 ± 2c

39 ± 14a

20 ± 6b

6 ± 3c

34 ± 8

23 ± 7b

4 ± 1c

Liver

11 ± 3a

1.9 ± 0.2

3 ± 1c

13 ± 4a

2.2 ± 0.7

2.1 ± 0.9c

15 ± 3a

2.7 ± 0.8

2.3 ± 0.7c

Spleen

35 ± 8a

17 ± 3

18 ± 4c

44 ± 14a

18 ± 4

13 ± 5c

40 ± 12

24 ± 10

10 ± 3c

Stomach

28 ± 7

19 ± 4b

8 ± 2c

42 ± 13

25 ± 7b

6 ± 3c

53 ± 15

30 ± 15b

7 ± 2c

Kidney

0.04 ± 0.01

0.05 ± 0.01

0.04 ± 0.01

0.06 ± 0.02

0.06 ± 0.01

0.04 ± 0.02

0.06 ± 0.01

0.10 ± 0.03

0.14 ± 0.04c

Muscle

116 ± 35

86 ± 16

57 ± 19c

181 ± 52

118 ± 43b

47 ± 20c

194 ± 72

149 ± 59

41 ± 14c

Bone

46 ± 12a

27 ± 2

25 ± 5

87 ± 30a

38 ± 11

22 ± 6c

81 ± 7a

36 ± 4b

20 ± 8c

  1. aSignificant difference (p < 0.05) between 64Cu-CB-TE2A-GEEE-ZHER2:342 and 64Cu-CB-TE2A-G-ZHER2:342 at this time point.
  2. bSignificant difference (p < 0.05) between 64Cu-CB-TE2A-G-ZHER2:342 and 64Cu-NODAGA-ZHER2:S1 at this time point.
  3. cSignificant difference (p < 0.05) between 64Cu-CB-TE2A-GEEE-ZHER2:342 and 64Cu-NODAGA-ZHER2:S1 at this time point.