Figure 1

Synthesis of adamantanyl benzamide precursors 5–8. Reagents and conditions: (a) BBr3, CH2Cl2, 0 °C to rt, 48 h, quant. (b) PyBOP, DiPEA, CH2Cl2, rt, 18 h, 73% (6), 77% (7), 79% (8).
Synthesis of adamantanyl benzamide precursors 5–8. Reagents and conditions: (a) BBr3, CH2Cl2, 0 °C to rt, 48 h, quant. (b) PyBOP, DiPEA, CH2Cl2, rt, 18 h, 73% (6), 77% (7), 79% (8).