Table 1 Radiolabelling results and LogDoct,7.4 of [11C]1–3 and [11C]SMW139. Values are given as mean ± standard deviation.

From: Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation

Product

Isolated yield (GBq)*

RCY (%, d.c.)

RCP (%)

Am (GBq·µmol−1)*

LogDoct,7.4 (n = 3)

[11C]1 (n = 6)

5.0 ± 1.7

33 ± 9

97 ± 1

159 ± 77

2.88 ± 0.14

[11C]2 (n = 5)

3.9 ± 0.8

30 ± 8

97 ± 1

84 ± 59

2.93 ± 0.02

[11C]3 (n = 3)

5.1 ± 0.5

41 ± 9

99 ± 0

239 ± 90

2.71 ± 0.01

[11C]SMW139 (n = 10)

4.8 ± 1.0

37 ± 9

96 ± 2

209 ± 83

2.70 ± 0.01

  1. *Measured at end of synthesis.
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