Table 3 Metabolic profiles of [11C]1–3 and [11C]SMW139 in rat brain.

From: Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation

Brain

[11C]1

[11C]2

[11C]3

[11C]SMW139

15 min

45 min

15 min

45 min

15 min

45 min

15 min

45 min

Intact tracer (%)

82 ± 1

76 ± 2

67 ± 5

32 ± 4

62 ± 2

32 ± 2

79 ± 1

66 ± 2

Non-polar metabolites (%)

18 ± 1

24 ± 2

33 ± 5

68 ± 4

38 ± 2

68 ± 2

21 ± 1

34 ± 3

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