Figure 1 | Scientific Reports

Figure 1

From: JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

Figure 1

Effect of JIB-04 on cell viability and the cell cycle. (A) Viability of cells cultured after treatment with various doses of JIB-04 or 10 µM salinomycin for 24 hr. Cell viability of DMSO-treated cells was set as 1 (n = 3). (B) Representative histograms of the cell cycle distribution in three colorectal cancer cell lines after treatment with DMSO (control) or JIB-04 for 24 hr. Cell were stained with propidium iodide to detect their DNA content. (D) Bar graph representing relative cell populations in cell cycle phases G1, S, and G2/M. *p < 0.05, **p < 0.01, ***p < 0.001, compared with DMSO.

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