Figure 4 | Scientific Reports

Figure 4

From: JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

Figure 4

JIB-04 reduced the tumorigenic activity of colorectal CSCs in vivo. (A–F) BALB/c nude mice were injected subcutaneously with the indicated number of HCT116 cells (left; 2 µM JIB-04-treated cells, right; vehicle-treated cells) (A and D). Tumor size was measured on the indicated days after injection of HCT116 cells (B and E). The bar graph reflects the mean ± SD volume of developing tumors at 27 days after injection (C and F). (G) The numbers of mice developing tumors at the indicated days after inoculation of 1 × 105 tumor cells. (n = 5) *p < 0.05, **p < 0.01, ***p < 0.001, compared with DMSO.

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