Figure 3

ML tree of fungi sensu stricto and Fonticula sequences. In this case, the LG + R8 model with perturbation strength = 0.5 provided the best ML value. Numbers refer to bootstrap support (as in Fig. 2: ML/NJ/MP). At the right, eight examples of the most typical structures found in fungal HECT proteins. Domains are indicated as colored boxes. From top to bottom: Saccharomyces cerevisiae RSP5, S. cerevisiae TOM1, Laccaria bicolor TOM1 (Accession number XM_001877693.1), S. cerevisiae HUL4, Coccidioides immitis HUL4A (XM_001247392.2), S. cerevisiae HUL5, Fusarium verticilloides HUL5 (XM_018889203.1) and S. cerevisiae UFD4. Figures are drawn to scale; the HECT domains shown correspond to 300–310 amino acids.