Table 2 Conservation of HECT-interacting proteins.
S. cerevisiae HECTs | S. cerevisiae interacting proteins | Homo sapiens HECTs | H. sapiens interacting proteins | Function of HECT-interacting proteins in yeast | References |
|---|---|---|---|---|---|
RSP5 | UBC1 | NEDD4L, ITCH, SMURF1, WWP2 | UBE2K | Ubiquitin-conjugating enzyme | |
RSP5 | UBC4, UBC5 | NEDD4, NEDD4L, HECW1, HECW2, ITCH, SMURF1, SMURF2, WWP1, WWP2 | UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3 | Ubiquitin-conjugating enzymes | |
RSP5 | UBC6 | NEDD4L, HECW1, ITCH, WWP2 | UBE2J2 | Ubiquitin-conjugating enzyme | |
RSP5 | UBI4 | HECW1 | UBC | Polyubiquitin | |
RSP5 | RPN10 | NEDD4, NEDD4L, HUWE1, SMURF1 | PSMD4 | 26S proteasome regulatory subunit | |
RSP5 | RPO21 | NEDD4, WWP1, WWP2, ITCH, SMURF1 | POLR2A | DNA-directed RNA polymerase II subunit | |
RSP5 | RPB2 | NEDD4, HECW2, ITCH, WWP1 | POLR2B/RPB2 | DNA-directed RNA polymerase II subunit | |
RSP5 | RPB3 | NEDD4, ITCH, WWP1, WWP2 | POLR2C | DNA-directed RNA polymerase II subunit | |
RSP5 | RPB5 | NEDD4, ITCH, WWP2 | POLR2E | DNA-directed RNA polymerases I, II, and III subunit | |
RSP5 | RPB7 | WWP1 | POLR2G | DNA-directed RNA polymerase II subunit | |
RSP5 | SEC7 | ITCH | ARFGEF2 | Vesicular transport protein, guanine exchange factor | |
RSP5 | HSE1 | ITCH | STAM1, STAM2 | Vacuolar protein-sorting machinery | |
RSP5 | HSP82 | WWP1 | HSP90AA1 | ATP-dependent molecular chaperone | |
RSP5 | LHP1 | SMURF1 | SSB | tRNA maturation control | |
RSP5 | NFI1, SIZ1 | SMURF2 | PIAS3 | Sumo conjugation | |
TOM1 | MLC1 | HUWE1 | MYL6B | Myosin light chain | |
TOM1 | HSP82, HSC82 | HUWE1 | HSP90AA1, HSP90AB1, HSP90B1 | ATP-dependent molecular chaperones | |
UFD4 | UBC4 | TRIP12 | UBE2D1, UBE2D4 | Ubiquitin-conjugating enzyme |
