Figure 2 | Scientific Reports

Figure 2

From: Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification

Figure 2

The structure, components and differences in metabolism of iEC2812 and comparison of the endothelial subtype genome scale metabolic models iHUVEC2552, iHPAEC2588 and iHMVEC2565. (a) The distribution of reactions in RECON1 (inner circle) and iEC2812 (outer circle) divided into metabolic super subsystems. (b) The majority of essential genes are shared between each sub-type model, iHUVEC2552 and iHPAEC2588 overlap totally and iHMVEC2565 has one unique essential reaction. (c) The classifications of essential reactions by subsystem. Alanine/aspartatane, eicosanoids, exchange, glycerophosphlipid, miscellaneous, nucleotide, purine, sphingolipid, extracellular transport and nuclear transport.

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