Table 2 Targets with significant difference between control and at least one clone: M1 or M2 or M3 vs. MCF7 and MCtrl.
From: A proteomic analysis of an in vitro knock-out of miR-200c
Protein names | Gene | p-Value | fold increase | Expression | Function |
|---|---|---|---|---|---|
Anterior gradient protein 2 homolog | AGR2 | M2 vs Ctrl | M2 vs Ctrl | down | Migration |
2.82 × 10−4 | 0.397 | ||||
Alpha-aminoadipic semialdehyde dehydrogenase | ALDH7A1 | M2 vs Ctrl | M2 vs Ctrl | up | De-tox |
4.69 × 10−4 | 1.96 | ||||
Carbonic anhydrase 2 | CA2 | M2 vs Ctrl | M2 vs Ctrl | down | Unknown |
4.07 × 10−3 | 0.361 | ||||
Src substrate cortactin | CTTN;EMS1 | M2 vs Ctrl | M2 vs Ctrl | down | Migration |
4.67 × 10−4 | 0.743 | ||||
Aspartate aminotransferase | GOT2 | M3 vs Ctrl | M3 vs Ctrl | down | Metabolism |
1.38 × 10−4 | 0.556 | ||||
Glutathione S-transferase Mu 3 | GSTM3 | M1 vs Ctrl | M1 vs Ctrl | up | De-tox |
6.03 × 10−5 | 2.48 | ||||
M2 vs Ctrl | M2 vs Ctrl | ||||
1.50 × 10−7 | 6.17 | ||||
M3 vs Ctrl | M3 vs Ctrl | ||||
1.21 × 10−5 | 2.91 | ||||
Heat shock protein HSP 90-alpha | HSP90AA1 | M2 vs Ctrl | M2 vs Ctrl | up | Metabolism |
4.64 × 10−4 | 1.39 | ||||
D-3-phosphoglycerate dehydrogenase | PHGDH | M2 vs Ctrl | M2 vs Ctrl | up | Metabolism |
6.57 × 10−3 | 1.89 | ||||
Kynureninase | KYNU | M2 vs Ctrl | M2 vs Ctrl | up | Metabolism |
1 × 10−3 | 1.61 | ||||
DNA replication licensing factor MCM4 | MCM4 | M2 vs Ctrl | M2 vs Ctrl | down | De-tox |
2.12 × 10−4 | 0.761 | ||||
Ras-related protein Rab-14 | RAB14 | M2 vs Ctrl | M2 vs Ctrl | down | Migration |
1.23 × 10−5 | 0.595 | ||||
SH3 domain-binding glutamic acid-rich-like protein | SH3BGRL | M3 vs Ctrl | M3 vs Ctrl | up | Migration |
4.01 × 10−5 | 1.85 | ||||
4F2 cell-surface antigen heavy chain | SLC3A2 | M2 vs Ctrl | M2 vs Ctrl | up | Apoptosis |
7.09 × 10−6 | 2.91 | ||||
M3 vs Ctrl | M3 vs Ctrl | ||||
6.42 × 10−4 | 1.71 | ||||
Triosephosphate isomerase | TPI1 | M3 vs Ct | M3 vs Ctrl | down | Metabolism |
7.95 × 10−5 | 0.69 | ||||
Tropomyosin alpha-1 chain | TPM1 | M2 vs Ctrl | M2 vs Ctrl | up | Migration |
4.76 × 10−3 | 2.71 | ||||
UDP-glucose 6-dehydrogenase | UGDH | M2 vs Ctrl | M2 vs Ctrl | down | Migration |
3.67 × 10−6 | 0.155 | ||||
M3 vs Ctrl | M3 vs Ctrl | ||||
3.28 × 10-3 | 0.533 | ||||
Tryptophan-tRNA ligase | WARS | M2 vs Ctrl | M2 vs Ctrl | up | De-tox |
1.20 × 10−3 | 1.58 |
