Table 1 Gene set enrichment analysis (GSEA) for myelin gene sets.

From: Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes

Name of gene set

No. of genes

ES

NES

NOM p-value

FDR q-value

FWER p-value

Myelination genes (total gene set)

117

0.49

1.16

0.072

0.072

0.072

Oligodendrocyte precursor cell (OPC) specification and proliferation (subset 1)

13

0.42

0.85

0.721

0.766

0.997

Oligodendrocyte differentiation and myelination (subset 2)

48

0.48

1.09

0.309

0.441

0.779

Lipid (incl. cholesterol) biosynthesis and transport (subset 3)

29

0.62

1.37

0.037

0.165

0.156

Other genes involved in myelination and myelin-related disorders (subset 4)

26

0.53

1.16

0.234

0.443

0.627

  1. The GSEA performs running sum statistics and calculates an enrichment score for each of the selected myelin-related genes, considering their rank in the pre-ranked gene list from the SCZ GWAS. The significance of the score was calculated using 1,500 permutations of the ranked list. Abbreviations: ES – enrichment score; NES – normalized enrichment score; NOM – nominal p-value; FDR – false discovery rate; FWER – family-wise error rate.
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