Table 1 Effect of exogenous Sema3A on the behaviour of human osteosarcoma cells in vitro.

From: Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A

 

MC3T3

MG-63

Saos-2

MNNG/HOS

KHOS

Cell migration

−21 ± 2.3**

−29 ± 4.4**

−50 ± 9.3*

−18 ± 1.9**

−18 ± 3.1*

Alkaline phosphatase activity

+33 ± 1.5***

+79 ± 11.2**

+24 ± 6.3*

+3 ± 5.4

ND

OS-associated osteoclastogenesis

−23 ± 2.2**

−19 ± 0.7**

−48 ± 1.3***

−51 ± 2.0**

−48 ± 8.3**

  1. Cancer cell migration, osteoblast differentiation and osteoclast formation were assessed as described under Materials and Methods.
  2. Values are expressed as means ± SEM and are obtained from 3 different experiments. *p < 0.05, **p < 0.01, ***p < 0.001 from
  3. vehicle treated cultures. OS denotes osteosarcoma and ND denotes non-detected.
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