Figure 4
From: N-Alkylation of functionalized amines with alcohols using a copper–gold mixed photocatalytic system
N-Alkylation of Amines by the Cu–Au mixed photocatalytic system. (a) Non-symmetrical N,N-dialkylation. Reaction conditions: *1b (1.0 mmol), Cu/TiO2 (22 mg), Au/TiO2 (22 mg), triethylene glycol monomethyl ether (2 equiv), CPME (10 mL), hv, Ar, 50 °C, 13 h; CH3OH (5 mL), 50 °C, 6 h. †1b (1.0 mmol), Cu/TiO2 (22 mg), Au/TiO2 (22 mg), 8-chloro-1-octanol (2 equiv), CPME (10 mL), hv, Ar, 25 °C, 16 h; C2H5OH (5 mL), 25 °C, 16 h. (b) Synthesis of deuterated drugs. (c) Synergistic effect in the Cu–Au mixed photocatalytic system.
