Table 2 Causal estimates of the association of obesity-related traits on risk of CAD, excluding overlap SNPs.

From: Assessing causal estimates of the association of obesity-related traits with coronary artery disease using a Mendelian randomization approach

Methods

Exposure

BMI

HC

HC*

WC

WC*

WHR

WHR*

IVW method

OR

1.32

1.07

0.84

1.34

0.86

1.46

1.36

95% CI

1.06ā€“1.66

0.82ā€“1.39

0.71ā€“0.98

0.89ā€“2.01

0.65ā€“1.12

1.11ā€“1.94

1.03ā€“1.80

p-value

0.015

0.628

0.033

0.163

0.260

0.007

0.030

MR-Egger test

OR-slope

1.71

1.28

0.95

1.19

1.16

3.14

0.97

95% CI-slope

0.83ā€“3.53

0.63ā€“2.62

0.46ā€“1.95

0.27ā€“5.24

0.35ā€“3.87

0.90ā€“10.90

0.27ā€“3.50

p-value-slope

0.152

0.506

0.893

0.822

0.813

0.084

0.965

intercept

āˆ’0.007

āˆ’0.006

āˆ’0.003

0.003

āˆ’0.008

āˆ’0.020

0.010

95% CI

āˆ’0.036

āˆ’0.028ā€“0.016

āˆ’0.025ā€“0.017

āˆ’0.035ā€“0.041

āˆ’0.037ā€“0.022

āˆ’0.052ā€“0.012

āˆ’0.027ā€“0.047

p-value-intercept

0.466

0.598

0.724

0.873

0.616

0.231

0.600

Weighted median

OR

1.27

1.36

0.83

1.51

0.96

1.59

1.25

95% CI

1.04ā€“1.68

1.07ā€“1.84

0.67ā€“0.96

1.03ā€“2.29

0.74ā€“1.32

1.10ā€“2.29

0.87ā€“1.78

p-value

0.024

0.035

0.040

0.041

0.930

0.011

0.222

  1. *Indicates that this trait was adjusted for body mass index (BMI) in our study. R2 refers to the proportion of variance of the exposure explained by the instruments. Hip circumference (HC), waist circumference (WC), waist-hip ratio (WHR), odds ratio (OR), confidence interval (CI), instrumental variable (IV), inverse variance weighted (IVW). In the table, the standard deviations (SDs) for BMI, HC, WC and WHR are 4.770 (kg/m2), 8.455 (cm), 12.520 (cm) and 0.074, respectively. OR means that the change in odds in CAD with a 1-SD increase in each obesity-related trait. P-heterogeneity is derived from the Q statistic, and p-intercept is derived from the MR-Egger test.
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