Table 2 Performance of the miRNA levels to detect cervical neoplasia.

0Normal vs	ROC cut off	AUC	sensitivity	specificity	PLR	NLR	accuracy	PPV	NPV
SCC
miR-126-3p	3.68	0.91(0.84–0.99)	0.86	0.91	9.56	0.15	0.89	0.86	0.91
miR-20b-5p	5.83	0.94(0.89–0.98)	0.83	0.93	11.86	0.18	0.89	0.88	0.90
miR-451a	116.75	0.96(0.92–1.00)	0.91	0.95	18.20	0.09	0.93	0.91	0.95
miR-144-3p	106.92	0.95(0.90–1.00)	0.89	0.93	12.71	0.12	0.91	0.89	0.93
SCC + AD
miR-126-3p	3.53	0.89(0.82–0.96)	0.81	0.91	9.00	0.21	0.86	0.90	0.84
miR-20b-5p	5.83	0.90(0.85–0.96)	0.74	0.93	10.57	0.28	0.84	0.91	0.79
miR-451a	37.59	0.94(0.90–0.99)	0.83	0.91	9.22	0.19	0.87	0.90	0.85
miR-144-3p	23.46	0.93(0.89–0.98)	0.87	0.89	7.91	0.15	0.88	0.89	0.88
CIN3+
miR-126-3p	1.65	0.80(0.73–0.87)	0.69	0.82	3.87	0.38	0.74	0.87	0.61
miR-20b-5p	2.25	0.82(0.75–0.89)	0.71	0.77	3.06	0.38	0.73	0.84	0.61
miR-451a	6.10	0.87(0.81–0.93)	0.80	0.82	4.50	0.24	0.81	0.89	0.71
miR-144-3p	12.92	0.87(0.81–0.93)	0.75	0.88	6.02	0.28	0.80	0.91	0.67
CIN2+
miR-126-3p	1.65	0.78(0.72–0.85)	0.66	0.82	3.70	0.41	0.71	0.90	0.51
miR-20b-5p	1.55	0.80(0.73–0.86)	0.74	0.70	2.43	0.38	0.73	0.85	0.53
miR-451a	5.95	0.85(0.79–0.91)	0.76	0.82	4.26	0.29	0.78	0.91	0.60
miR-144-3p	17.84	0.85(0.79–0.91)	0.68	0.89	6.39	0.35	0.75	0.94	0.55

Note: ROC: receiver operating characteristic, AUC: area under the curve, PLR: positive likelihood ratio, NLR: negative likelihood ratio. PPV: positive predictive value, NPV: negative predictive value. The cut-off point was determined by the Youden index.
Estimation of AUC: 1.0: perfect match, 1.0–0.9: high accuracy, 0.9–0.7: moderate accuracy, 0.7–0.5: low accuracy, 0.5: chance result¹⁸.

Quick links

Search